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MATHEMATICS FOR CRYO-ELECTRON MICROSCOPY

    https://doi.org/10.1142/9789813272880_0209Cited by:10 (Source: Crossref)
    Abstract:

    Single-particle cryo-electron microscopy (cryo-EM) has recently joined X-ray crystallography and NMR spectroscopy as a high-resolution structural method for biological macromolecules. Cryo-EM was selected by Nature Methods as Method of the Year 2015, large scale investments in cryo-EM facilities are being made all over the world, and the Nobel Prize in Chemistry 2017 was awarded to Jacques Dubochet, Joachim Frank and Richard Henderson “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution”. This paper focuses on the mathematical principles underlying existing algorithms for structure determination using single particle cryo-EM.

    Partially supported by Award Number R01GM090200 from the NIGMS, FA9550-17-1-0291 from AFOSR, Simons Foundation Math+X Investigator Award, and the Moore Foundation Data-Driven Discovery Investigator Award.
    MSC2010: primary 92C55, secondary 68U10, secondary 44A12, secondary 62H12, secondary 33C55, secondary 90C22