ENHANCED BIOACTIVITY OF POLED STRONTIUM HYDROXYAPATITE CERAMICS

Biocompatibility of polarized strontium hydroxyapatite (SrHAp: Sr₁₀(PO₄)₆(OH)₂) ceramics was studied in terms of the bone-like crystal growth as well as the cell reaction. The ceramics of SrHAp were prepared from SrHAp powders were synthesized by a wet-method. The polarized ceramics were immersed for 12h, 1, 3, and 5 days in three types of media such as simulated body fluid, α-minimum essential medium (α -MEM),and α -MEM with included 10% fetal bovine serum.

The soaked ceramics were analyzed by X-ray diffraction, and grown crystals on ceramics surface were observed by scanning electron microscope. Crystals on negatively charged surface (N-surface) were well grown in every medium than those on the positively charged surface (P-surface). Cell cultivation revealed that osteoblast like cells (MC3T3-E1) grew on the surface of non-polarized and polarized ceramics for 1,3,and 4days. The MC3T3-E1 cells were more strongly adhered to N-surface than to P-surface.