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Chapter 12: Evolutionary dynamics in hierarchical populations
https://doi.org/10.1142/9789814566377_0012Cited by:0 (Source: Crossref)
Abstract:
The following sections are included:
Introduction
Types of stem cells divisions
The set-up
Methodology
Analysis of the Moran process
Numerical simulations
Generation of mutations in a hierarchical population
Tunneling rates
Double-hit mutants are produced slower under symmetric compared to asymmetric divisions
Comparison with the homogeneous model
The optimal fraction of stem cells
Do mutations in TA cells produce double-mutants?
Biological discussion
Symmetric divisions can have a cancer-delaying effect
Can TA cells create double-hit mutants?
Cancer stem cell hypothesis
Summary
Problems
