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THE EFFECT OF HIGH AND LOW FREQUENCY CORTICAL STIMULATION WITH A FIXED OR A POISSON DISTRIBUTED INTERPULSE INTERVAL ON CORTICAL EXCITABILITY IN RATS

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

The author contributed equally to this work.

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ALFRED MEURS

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

Corresponding author.

The author contributed equally to this work.

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ROBRECHT RAEDT

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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VEERLE DE HERDT

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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LEEN DECORTE

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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LAURENCE BERTIER

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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JEAN DELBEKE

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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WYTSE WADMAN

Swammerdam Institute of Life Sciences, Department of Neurobiology, University of Amsterdam, Sciencepark 904, 1090 Amsterdam, The Netherlands

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KRISTL VONCK

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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PAUL BOON

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium

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https://doi.org/10.1142/S0129065714300058Cited by:9 (Source: Crossref)

Abstract

Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response - 100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.

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