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Study of Sokei-Kakketu-To (Shu-Jing-Huo-Xue-Tang) in Adjuvant Arthritis Rats

Kansai College of Oriental Medicine, Osaka 590-0482, Japan

Department of Pharmacology, Kinki University School Medicine, Osaka 589-8511, Japan

Correspondence to: Dr. Shigeyuki Kanai, Kansai College of Oriental Medicine, 2-11-1 Wakaba Kumatori-cho Sennan-gun, Osaka 590-0482, Japan. Tel: (+81) 7-2453-8251, Fax: (+81) 7-2453-0276.

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Norimasa Taniguchi

Kansai College of Oriental Medicine, Osaka 590-0482, Japan

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Hideaki Higashino

Department of Pharmacology, Kinki University School Medicine, Osaka 589-8511, Japan

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https://doi.org/10.1142/S0192415X03001600Cited by:13 (Source: Crossref)

Abstract

To examine the effectiveness of the herbal medicine prescription, Shu-Jing-Huo-Xue-Tang (SJHXT), for pain relief, we performed a study using rats with adjuvant arthritis (AA). After injecting the adjuvant, AA rats were maintained for 6 months as a chronic pain model. Starting at 6 months, SJHXT was administered for 12 weeks. We measured the tail skin temperature and locomotor activity of rats using thermography and a metabolism measuring system, respectively, before and after 12 weeks of SJHXT administration. Normal rats were used as controls. Before SJHXT administration, the tail surface temperature and locomotor activity were significantly lower in the AA rats than in the control rats. The tail skin temperature and locomotor activity of SJHXT-treated AA rats were significantly higher than those of the control rats. These findings suggest that the pain relief effects of SJHXT may be primarily due to increased blood circulation.

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