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Electroacupuncture on PC6 (Neiguan) Attenuates Ischemia/Reperfusion Injury in Rat Hearts

Meng-Ting Tsou

Institute of Traditional Medicine, National Yang-Ming University, Taipei, ROC

Department of Family Physicians, Mackay Memorial Hospital, Taipei, ROC

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Cheng-Hsiung Huang

Department of Surgery School of Medicine, National Yang-Ming University, Taipei, ROC

Divisions of Cardiovascular Surgery, Veterans General Hospital, Taipei, ROC

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Jen-Hwey Chiu

Institute of Traditional Medicine, National Yang-Ming University, Taipei, ROC

General Surgery Department of Surgery, Veterans General Hospital, Taipei, ROC

Department of Surgery, Cheng Hsin Rehabilitation Medical Center, Taiwan, ROC

Correspondence to: Dr. Jen-Hwey Chiu, Institute of Traditional Medicine, National Yang-Ming University, No.155, Li-Nong Street, Sec. 2, Peitou, Taipei 112, Taiwan. Fax: (+886) 2-2875-7537.

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https://doi.org/10.1142/S0192415X04002557Cited by:46 (Source: Crossref)

Abstract

The use of somato-visceral regulation has been proposed as a treatment for a wide range of diseases. The aim of this study was to test the hypothesis that through somato-visceral regulation, ischemia-reperfusion (I/R) injury to the myocardium can be avoided by electroacupuncture (EA) on PC6 (Neiguan).

Electroacupuncture on PC6 (Neiguan) was brought about by the application of metal needles over the bilateral median nerve at a point 1.5 cm proximal to the palm crease in male Spraque-Dawley rats. The animals were randomized into two groups: (1) prevention group with preconditioning by the application of EA on PC6 (n=13); and (2) treatment group with EA on PC6 during I/R injury (n=10). The protection against myocardial injury was blocked by different mechanisms: (1) severing of the bilateral median nerve (n=10), (2) bilateral vagotomy (n=10), and (3) intravenous naloxone injection (n=10). The hemodynamic parameters (mean artery pressure and heart rate), duration of arrhythmia, mortality rate and cardiac enzymes were evaluated in these groups. The results showed that there were significant reductions in cardiac enzymes, the duration of arrhythmia and mortality rate in rats that were either preconditioned or treated with EA on PC6, compared with those that did not undergo EA on PC6 (P<0.05). The cardioprotective effects were blocked by different procedures (P>0.05).

We conclude that EA on bilateral PC6 (Neiguan) prevents and attenuates I/R injury to the heart, and that this approach may provide an applicable and preventative alternative for patients with ischemic heart disease.

Keywords:

References

R. M. Bauer, G. A. Iwamoto and T. G. Waldrop, Am. J. Physiol. 257, R1154 (1989). Medline, Google Scholar
Q. Caoet al., J. Tradit. Chin. Med. 18, 134 (1998). Medline, Web of Science, Google Scholar
D. Caringiet al., Am. J. Physiol. 274, H139 (1998). Medline, Google Scholar
S. L. Changet al., Diabetologia 42, 250 (1999). Medline, Web of Science, Google Scholar
D. M. Chaoet al., Am. J. Physiol. 276, 2127 (1999). Google Scholar
S. Z. Chen, Clin. J. Acupunct. Moxib. 10, 30 (1994). Web of Science, Google Scholar
J. H. Chiuet al., Can. J. Vet. Res. 67, 94 (2003). Medline, Web of Science, Google Scholar
J. H. Chiuet al., Dig. Dis. Sci. 44, 1759 (1999). Medline, Web of Science, Google Scholar
A. J. Coatset al., Circulation 85, 2119 (1992). Medline, Web of Science, Google Scholar
S. G. Elliset al., Circulation 106, 1205 (2002). Medline, Web of Science, Google Scholar
R. F. Heimburger, Arch. Surg. 52, 677 (1946). Medline, Web of Science, Google Scholar
G. Heusch, A. Deussen and V. Thamer, J. Auton. Nerv. Syst. 13(4), 311 (1985). Medline, Google Scholar
C. Y. Hong, S. S. Huang and S. K. Tsai, Clin. Exp. Pharmacol. 23, 660 (1996). Web of Science, Google Scholar
E. M. Huang, Q. Z. Feng and P. Hu, Acupunct. Res. 16, 108 (1991). Google Scholar
D. H. Huangfu and P. Li, Chin. J. Physiol. Sci. 4, 115 (1988). Google Scholar
I. Kenedi and A. Losonci, Acta. Physiol. Acad. Sci. Hung. 43, 133 (1973). Medline, Google Scholar
D. R. Kostreva, Basic Res. Cardiol. 86, 523 (1991). Medline, Web of Science, Google Scholar
K. Krogeret al., Eur. Heart J. 10(), 179 (1989). Medline, Web of Science, Google Scholar
H. D. Kuo, G. Y. Chen and H. M. Lo, Crit. Care Med. 28, 1283 (2000). Medline, Web of Science, Google Scholar
M. T. La Rovereet al., Lancet 358, 478 (1998). Medline, Web of Science, Google Scholar
P. Li, News Physiol. Sci. 6, 69 (1991). Google Scholar
P. Li, Mechanism of the Modulatory Effect of Acupuncture on Abnormal Cardiovascular Function, eds. P. Li and T. Yao (Shanghai Medical University Press, Shanghai, China, 1992) pp. 1–5. Google Scholar
P. Liet al., Circulation 97, 1186 (1998). Medline, Web of Science, Google Scholar
P. Liet al., Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R1335 (2002). Medline, Web of Science, Google Scholar
P. Li, S. Tjeng-A-Looi and J. C. Longhurst, Auton. Neurosci. 89, 38 (2001). Medline, Web of Science, Google Scholar
Y. H. Linet al., J. Surg. Res. 99, 328 (2001). Medline, Web of Science, Google Scholar
F. Liuet al., Research on Acupuncture, Moxibustion and Acupuncture Anesthesia, ed. H. T. Change (Science Press and Springer Verlag, Beijing, China, 1986) pp. 861–875. Google Scholar
A. Malliani, Basic Res. Cardio. 85(), 243 (1990). Medline, Web of Science, Google Scholar
K. Nishijoet al., Neurosci. Lett. 227, 165 (1997). Medline, Web of Science, Google Scholar
A. Sato, Y. Sato and R. F. Schmidt, Rev. Physicol. Biochem. Pharmacol. 130, 1 (1997). Medline, Web of Science, Google Scholar
A. Sato, Y. Sato and A. Suzuki, Biomed. Res. 15, 59 (1994). Web of Science, Google Scholar
J. F. Stebbing, Ann. Roy. Coll. Surg. Eng. 80, 137 (1998). Medline, Web of Science, Google Scholar
S. Y. Sunet al., Gen. Pharmacol. 27, 1187 (1996). Medline, Google Scholar
N. Tiedt and A. Religa, Basic Res. Cardiol. 74, 266 (1979). Medline, Web of Science, Google Scholar
E. Vanoli, D. Cerati and R. F. Pedretti, Basic Res. Cardiol. 93(), 133 (1998). Medline, Web of Science, Google Scholar
E. Vanoli and P. J. Schwartz, Basic Res. Cardiol. 85(), 305 (1990). Medline, Web of Science, Google Scholar
M. J. Walkeret al., Cardiovasc. Res. 22, 447 (1988). Medline, Web of Science, Google Scholar
World Health. Acupuncture and Moxibustion. World Health Organization, February 1980 . Google Scholar
T. Yao and P. Li, Mechanism of the modulatory effect of acupuncture on abnormal cardiovascular function, eds. P. Li and T. Yao (Shanghai Medical University Press, Shanghai, China, 1992) pp. 13–31. Google Scholar