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Electroacupuncture Promotes Insulin-Like Growth Factors System in Ovariectomized Osteoporosis Rats

Department of Neurobiology and Integrative Medicine, Institution of Acupuncture Research (WHO Collaborating Center for Traditional Medicine, Research Department of Acupuncture) and Institute of Neurobiology, Fudan University, Shanghai 200032, China

The first two authors contributed equally to this work.

Correspondence to: Dr. Yi Feng, Department of Neurobiology and Integrative Medicine, Institution of Acupuncture Research, 138 Yi-Xue-Yuan Road, Shanghai Medical College of Fudan University, Shanghai 200032, China. Tel: (+86) 21-5423-7693, Fax: (+86) 21-6575-9522.

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Department of Orthopaedics, the Second Hospital of Beijing Municipal Corps, Chinese People's Armed Police, Beijing 100037, China

The first two authors contributed equally to this work.

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Department of Acupuncture and Moxibustion and Department of Gynecology and Obstetrics, Hubei University of Traditional Chinese Medicine, Wuhan 430061, China

Department of Traditional Chinese Medicine, Medical School of Jianghan University, Wuhan 430056, China

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Department of Acupuncture and Moxibustion and Department of Gynecology and Obstetrics, Hubei University of Traditional Chinese Medicine, Wuhan 430061, China

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Department of Acupuncture and Moxibustion and Department of Gynecology and Obstetrics, Hubei University of Traditional Chinese Medicine, Wuhan 430061, China

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Department of Acupuncture and Moxibustion and Department of Gynecology and Obstetrics, Hubei University of Traditional Chinese Medicine, Wuhan 430061, China

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Department of Acupuncture and Moxibustion and Department of Gynecology and Obstetrics, Hubei University of Traditional Chinese Medicine, Wuhan 430061, China

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Department of Traditional Chinese Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

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https://doi.org/10.1142/S0192415X08006326Cited by:25 (Source: Crossref)

Abstract

Postmenopausal Osteoporosis (PMOP) is induced by the deficiency of estrogen in postmenopausal women. Electroacupuncture (EA) has been confirmed to be effective in clinic. We adopted ovariectomized osteoporosis model of rats to observe the role of EA in PMOP. Fifty female SD rats were divided randomly into 5 groups: intact (INT, n = 10), sham operation (Sham, n = 10), model (n = 10), estrogen (E, n = 10) and electroacupuncture (EA, n = 10). The bone mineral content (BMC) and the bone mineral density (BMD) were examined in lumbar_1–6 and right thigh-bone, respectively, and estrodiol (E₂), insulin-like growth factor I (IGF-I) and insulin-like growth factor binding proteins (IGF-BPs) were tested by RIA or ELISA. The results showed that BMC and BMD of lumbar 1–6 and right thigh-bone in PMOP model rats decreased markedly, while the level of serum E₂, IGF-I and IGF-BP1 were lower than in INT and Sham. However, EA could upgrade the contents of IGF-I and IGF-BP1 to increase BMD in PMOP rats, while no significant difference was seen in E group. Therefore, EA may promote IGF system to improve PMOP.

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