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A STRUCTURE-MOTIVATED MODEL OF THE PASSIVE MECHANICAL RESPONSE OF THE PRIMARY PORCINE RENAL ARTERY

College of Engineering and Computing, Biomedical Engineering Program, University of South Carolina, Columbia, SC, 29208, USA

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LAUREN WOLF

College of Engineering and Computing, Biomedical Engineering Program, University of South Carolina, Columbia, SC, 29208, USA

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ALEXANDER RACHEV

College of Engineering and Computing, Biomedical Engineering Program, University of South Carolina, Columbia, SC, 29208, USA

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, and

TAREK SHAZLY

College of Engineering and Computing, Biomedical Engineering Program, University of South Carolina, Columbia, SC, 29208, USA

College of Engineering and Computing, Mechanical Engineering Department, University of South Carolina, Columbia, SC, 29208, USA

Corresponding author.

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https://doi.org/10.1142/S021951941450033XCited by:13 (Source: Crossref)

Abstract

The primary renal arteries transport up to one fourth of cardiac output to the kidneys for blood plasma ultrafiltration, with a functional dependence on the vessel geometry, composition and mechanical properties. Despite the critical physiological function of the renal artery, the few biomechanical studies that have focused on this vessel are either uniaxial or only partially describe its bi-axial mechanical behavior. In this study, we quantify the passive mechanical response of the primary porcine renal artery through bi-axial mechanical testing that probes the pressure-deformed diameter and pressure-axial force relationships at various longitudinal extensions, including the in-vivo axial stretch ratio. Mechanical data are used to parameterize and validate a structure-motivated constitutive model of the arterial wall. Together, experimental data and theoretical predictions of the stress distribution within the arterial wall provide a comprehensive description of the passive mechanical response of the porcine renal artery.

Keywords:

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