NUMERICAL ESTIMATION OF DRUG DIFFUSION AT DERMAL REGIONS OF HUMAN BODY IN TRANSDERMAL DRUG DELIVERY SYSTEM
Abstract
A mathematical model is proposed to study the amount of drug concentration at various regions of human dermal system. The model is based on the mechanism of transdermal drug delivery systems (TDDS) with appropriate boundary conditions. The analytical solution for such problems either does not exist or is too complicated to handle. In this paper, finite element and Crank–Nicholson methods were used to find the solution of the formulated model with greater accuracy.