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Photophysical, photochemical and bovine serum albumin binding studies on water-soluble gallium(III) phthalocyanine derivatives

Abimbola Ogunsipe

Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa

Department of Chemistry, University of Lagos, Lagos, Nigeria

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Tebello Nyokong

Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa

SPP full member in good standing

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, and

Mahmut Durmuş

Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa

Gebze Institute of Technology, Department of Chemistry, PO Box 141, Gebze, 41400, Turkey

Corresponding author, fax: +90 262-6538490

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https://doi.org/10.1142/S1088424607000746Cited by:22 (Source: Crossref)

Abstract

Spectral, photophysical, photochemical and bovine serum albumin binding studies on some gallium(III) derivatives - {1,(4)-(tetrapyridyloxyphthalocyaninato)gallium(III), (αGaPc); 2,(3)-(tetrapyridyloxyphthalocyaninato)gallium(III), (βGaPc); and their quaternized derivatives: QαGaPc and QβGaPc)} are hereby presented. β-Substituted complexes are more fluorescent, but show lower tendencies to undergo intersystem crossing than the α-substituted, as judged by their fluorescence and triplet quantum yield values. The quaternized derivatives (QGaPc) are water-soluble and non-aggregated, which makes them potential photosensitizers of choice for photodynamic therapy applications; these amphiphilic compounds also bind strongly to bovine serum albumin in 1:1 stoichiometries, and with binding constants (K_b) in the order of 10⁶ M⁻¹.

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