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DNA-binding, photocleavage and anti-cancer activity of tin(IV) corrole

An-Na Xie

Department of Chemistry, South China University of Technology, Guangzhou 510640, P.R. China

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Zhao Zhang

Department of Chemistry, South China University of Technology, Guangzhou 510640, P.R. China

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Hua-Hua Wang

Department of Chemistry, South China University of Technology, Guangzhou 510640, P.R. China

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Atif Ali

Department of Chemistry, South China University of Technology, Guangzhou 510640, P.R. China

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Dong-Xu Zhang

Department of Chemistry, South China University of Technology, Guangzhou 510640, P.R. China

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Hui Wang

State Key Laboratory of Optoelectronics Materials and Technologies, Sun-Yat Sen University, Guangzhou 510275, P.R. China

E-mail Address: stswh@mail.sysu.edu.cn

Corresponding author

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Liang-Nian Ji

State Key Laboratory of Optoelectronics Materials and Technologies, Sun-Yat Sen University, Guangzhou 510275, P.R. China

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, and

Hai-Yang Liu

Department of Chemistry, South China University of Technology, Guangzhou 510640, P.R. China

E-mail Address: chhyliu@scut.edu.cn

Correspondence to: Haiyang Liu, tel.: +86-20-22236805, fax: +86-20-22236805

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https://doi.org/10.1142/S1088424618500256Cited by:17 (Source: Crossref)

Abstract

A new tin(IV) corrole, 5,10,15-tris(4-methoxycarbonylphenyl) corrole tin(IV) (1-Sn) was synthesized and characterized. The DNA binding, photocleavage and anti-cancer activity were studied and compared with its free-base. The interaction of 1-Sn and its free-base 1 with calf thymus DNA had been investigated by spectroscopic methods, viscosity measurements and molecular docking analysis. The results revealed that 1-Sn and 1 could interact with calf thymus DNA via an outside groove binding mode. Furthermore, although 1 displayed no photonuclease activity, 1-Sn exhibited good photonuclease activity as indicated by agarose gel electrophoresis, and superoxide anion might be the active intermediate for the DNA scission. Finally, 1 was nontoxic but 1-Sn displayed cytotoxicity towards A549 tumor cell lines.

Dedicated to Professor Naisheng Chen on the occasion of his 80th birthday

Keywords:

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