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Synthesis of Nano-Hydroxyapatite of Different Morphologies and Their Cellular Compatibility

School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

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Haishan Deng

School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

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Shun Yao

School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

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Pan Ma

School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

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Minchi Cao

School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

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, and

Youfa Wang

School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, P. R. China

State Key Laboratory of Advanced Technology for Materials, Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, P. R. China

E-mail Address: wangyoufa@whut.edu.cn

Corresponding author.

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https://doi.org/10.1142/S1793292020501404Cited by:1 (Source: Crossref)

Abstract

Nano-hydroxyapatite crystals of different morphologies were synthesized by adding two types of amino acids (glycine and arginine) under hydrothermal conditions. The XRD, FTIR, and TEM characterizations of samples showed that the final product was pure hydroxyapatite with high crystallinity. Organic small-molecule amino acids exhibited a significant inhibitory effect on crystal growth during the synthesis process. This regulatory effect is related to the side chains of amino acids. The results of co-culturing with bone mesenchymal stem cells showed that the cell compatibility of nanoparticles differs based on their morphologies. The results of this study are significant for the fabrication of nano-hydroxyapatite with tunable morphology, which can have applications in the fields of bone repair and drug loading.

Keywords:

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