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MiRNA:RBP Interplay as a Key Regulatory Element in Health and Disease

Marcos G. Teneche

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, Spain

Cancer Science Institute of Singapore, National University of Singapore, Singapore

E-mail Address: mgteneche@gmail.com

Corresponding author.

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Neus Carbó

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, Spain

Institute of Biomedicine of the University of Barcelona (IBUB), Spain

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, and

F. Javier Casado

Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, University of Barcelona, Barcelona, Spain

Institute of Biomedicine of the University of Barcelona (IBUB), Spain

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https://doi.org/10.1142/S2591722620400098Cited by:0 (Source: Crossref)

Abstract

Numerous crosstalk interactions between RNA-binding proteins (RBPs) and microRNAs (miRNAs) have been recently reported, unveiling the complexity and importance of gene expression modulation in health and disease. They control physiological processes such as stem cell maintenance, neuronal development or energetic metabolism, but are also responsible for pathological conditions, such as muscle waste and dystrophies, atherosclerosis, obesity and cancer. MiRNAs and RBPs are two of the well-studied post-transcriptional regulators and they may even reciprocally regulate themselves. MiRNAs can act on RBPs expression while RBPs modulate miRNA biogenesis, function and degradation. RBPs and miRNAs modulate mRNA expression at different levels, affecting their stability, splicing and translation efficiency through either competition for overlapping binding or modulation of mRNA structure by binding, but several other forms of interaction have been described. In this review, we will address the current bibliography regarding miRNA:RBP interactions and crosstalk events as well as their implications in health and disease.

Keywords:

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