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IMMUNOMODULATORY EFFECTS OF FAR-INFRARED RAY IRRADIATION VIA INCREASING CALMODULIN AND NITRIC OXIDE PRODUCTION IN RAW 264.7 MACROPHAGES

Department of Radiology, School of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan

Breast Health Center, Taipei Medical University Hospital, Taipei, Taiwan

Department of Applied Cosmetology and Graduate Institute of Cosmetic Science, Hungkuang University, Taichung, Taiwan

Instrument Technology Research Center, National Applied Research Laboratories, Hsinchu, Taiwan

Corresponding author: Yung-Sheng Lin, No. 34, Chung-Chie Road, Shalu, Taichung, 443, Taiwan, R.O.C. Tel: +886-4-26318652, ext. 3684; Fax: +886-4-26321046.

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Yen-Chou Chen

Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan

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Huey-Fang Shang

Department of Microbiology and Immunology, School of Medicine, Taipei Medical University, Taipei, Taiwan

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Yi-Hsuan Lee

Department of Physiology, School of Medicine, Taipei Medical University, Taipei, Taiwan

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Ching-Hua Su

Department of Microbiology and Immunology, School of Medicine, Taipei Medical University, Taipei, Taiwan

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Huang-Chu Liao

Department of Radiology, School of Medicine, Taipei Medical University and Hospital, Taipei, Taiwan

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, and

Tsong-Min Chang

Department of Applied Cosmetology and Graduate Institute of Cosmetic Science, Hungkuang University, Taichung, Taiwan

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https://doi.org/10.4015/S1016237209001404Cited by:20 (Source: Crossref)

Abstract

Far-infrared ray (FIR) radiation has been shown to be beneficial to human health; however, little scientific evidence of its mechanisms has been provided. In the present study, we investigated the effect of nonthermal-enhanced FIR on the expression of calmodulin (Cam) protein and nitric oxide (NO) production by RAW 264.7 macrophages. Results indicated a significant increase in Cam protein in FIR-treated RAW 264.7 macrophages with or without the addition of lipopolysaccharide (LPS). In addition, the amount of NO was slightly higher but increased significantly in FIR plus LPS-treated RAW 264.7 macrophages. Data of the present study provide the first evidence to indicate the immunomodulatory properties of FIR through increasing Cam protein and NO production in RAW 264.7 macrophages.

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