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Chapter 18: Tumor growth kinetics and disease progression
https://doi.org/10.1142/9789814566377_0018Cited by:0 (Source: Crossref)
Abstract:
In Part 2 of the book, a mathematical framework was developed to study the evolutionary dynamics of mutant generation during tumor growth. An obvious application of this framework is the generation of mutants that are resistant to drug therapy, and the theory was developed in this context. The current chapter explores implications of this mathematical framework for the evolution of tumor cells, namely, the progression of cancers towards increased malignancy…
