Narrow Results

Philips and EDBI to Jointly Invest in Digital Health Companies as Healthcare Demand in Asia Rises with Ageing Population.

The Abraaj Group Agrees to Acquire a Majority Stake in CARE Hospitals, a Leading Healthcare Provider in India, from Advent International.

Quad Technologies Collaborates with University of Massachusetts Medical School to Highlight Benefits of Novel Cell Separation Solution.

Gyros AB Extends Capabilities of Gyrolab Automated Immunoassay Platform with New Affinity Software Module.

ASLAN Pharmaceuticals Appoints World Leading Experts to its Scientific Advisory Board.

GoodFuels Marine Receives Highest Standard Certification for Its Sustainable Marine Biofuels.

Philip Morris International Publishes Science on Heated Tobacco in Leading Peer-Reviewed Journal.

Verseon Presents Data on a New Class of Anti-coagulants at the 8th Biotech Showcase Conference.

CIDP Group Inaugurates First Asia Subsidiary in Singapore.

When a drug enters an organism, interactions between the drug and proteins in the organism play a vital role in the storage, transport and metabolism of the drug and also affect its nonspecific toxicity, targeting and pharmacodynamic activity. However, monitoring the interaction process is a great challenge in the research of the absorption, transport and metabolic processes of drugs. In this study, we used reflectometric interference spectroscopy (RIfS) and silica colloidal crystal (SCC) film as a sensing platform to detect the binding affinity between human serum albumin (HSA) and indomethacin. SCC films composed of three silica nanospheres with different diameters were fabricated using the vertical evaporation method. HSA was immobilized covalently on SCC film using a very simple approach, and optical thickness was used as a parameter to evaluate the process of drug absorption and desorption. Finally, the optimal SCC film was selected, and three drugs other than indomethacin (i.e., warfarin, salicylic acid and quinine) were used for the validation of this sensing platform. The results verified that SCC film using RIfS is a simple and real-time sensing platform for detecting the affinity between HSA and drugs, which may be widely used in drug development and clinical testing in the future.