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Heat pipes are devices of very high heat transfer capability and have been widely used in many thermal management applications. An experimental investigation and CFD simulation of thermal characteristics of heat pipe was presented in this paper. It can be found that UDF in FLUENT can simulate the evaporation and condensation in heat pipe. Phase change happened in evaporation section of heat pipe is boiling. In steady state, the fluctuation of axial velocity is very small in the most area (without evaporation section) in heat pipe. In general, the magnitudes of velocity vary from 0 to maximum from the end of both evaporation section and condenser, and the maximum value was maintained in the adiabatic section.