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Gold supported hydroxyapatite (HA) and calcium deficient hydroxyapatite (CDHA) was studied for the room temperature CO oxidation. Nanostructured gold catalyst has been prepared by deposition precipitation method, whereas HA was synthesized by microwave synthesis. Inorder to understand the influence of surface properties of HA, support HA was synthesized with different Ca/P ratios (1.67, 1.62, 1.57, 1.534 and 1.5). The gold supported catalysts were characterized by XRD, BET, ICP-OES and TEM. Typical results indicate that gold supported 1.57 HA shows higher activity compared to other HA catalysts (1.67, 1.62, 1.534 and 1.5) which may be due to the presence of optimum number of acidic and basic sites.