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    COMPANY NEWS

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      Special Feature

        An Overview — Molecular Diagnostics.

        Interview with Mr Michael Tillmann, Managing Director, Roche Diagnostics, Asia Pacific.

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        Developing a Complete Molecular Diagnostic Solution: Multiplex Analysis, High Performance, High Throughput and Automation.

        Interview with QIAGEN World Leader in Molecular Diagnostics Solutions.

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        HEALTH COLUMNS

          World Heart Day – At the Heart of Health

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          INSIDE INDUSTRY

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            APBN Interview with Professor Chng Wee Joo.

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            COMPUTER AIDED DIAGNOSIS FOR CARDIOVASCULAR DISEASES BASED ON ECG SIGNALS: A SURVEY

            The interpretation of Electroencephalography (ECG) signals is difficult, because even subtle changes in the waveform can indicate a serious heart disease. Furthermore, these waveform changes might not be present all the time. As a consequence, it takes years of training for a medical practitioner to become an expert in ECG-based cardiovascular disease diagnosis. That training is a major investment in a specific skill. Even with expert ability, the signal interpretation takes time. In addition, human interpretation of ECG signals causes interoperator and intraoperator variability. ECG-based Computer-Aided Diagnosis (CAD) holds the promise of improving the diagnosis accuracy and reducing the cost. The same ECG signal will result in the same diagnosis support regardless of time and place. This paper introduces both the techniques used to realize the CAD functionality and the methods used to assess the established functionality. This survey aims to instill trust in CAD of cardiovascular diseases using ECG signals by introducing both a conceptional overview of the system and the necessary assessment methods.

          • articleNo Access

            EFFECTIVE FEATURES ANALYSIS IN PARALLEL DIAGNOSIS OF CARDIOVASCULAR DISEASES USING HEART SOUND

            Heart sound signal processing is a low-cost, and noninvasive method for the early diagnosis of various types of cardiovascular diseases. In this study, a parallel diagnosing method was proposed to detect various types of heart diseases and healthy heart samples. The proposed system can detect a person who might be simultaneously suffering from two or more heart diseases. Contributing to this line of investigation, effective features were obtained from the morphological and statistical features extracted from five frequency ranges of heart sounds. Applying such features in diagnosing any heart disease acts as a fingerprint specific to that disease. Therefore, the investigation of selected features, especially in each of the frequency ranges of heart sounds and murmurs, provided us with valuable information about the behavior of the diagnostic system in the detection of heart diseases. In addition to using features related to the nature of heart sounds, the proposed method of this study got rid of both the need to apply different filters needed to remove noise and dependence on a specific dataset. With the aid of the effective features in the parallel diagnosis of 15 different types of important and common heart diseases and a healthy class from each other, the diagnostic system of the present study was able to achieve the average accuracy of 97.06%, the average sensitivity of 97.99%, and the average specificity of 96.18% in the shortest possible time. The proposed approach is an important step in the screening and remote monitoring and tracking of disease progression.

          • articleOpen Access

            Integration of Current Clinical Knowledge with a Data Driven Approach: An Innovative Perspective

            Cardiovascular diseases are the leading cause of death worldwide. The development of models to support clinical decision is of great importance in the management of these diseases. This work aims to improve the performance exhibited by risk assessment scores that are applied in the clinical practice. This methodology has three main phases: (i) representation of scores as a decision tree; (ii) optimization of the decision tree thresholds using data from recent clinical datasets; (iii) transformation of the optimized decision tree into a new score.

            This approach was validated in a cardiovascular disease secondary prevention context, supported by a dataset provided by the Portuguese Society of Cardiology (N=13902). The respective performance was assessed using statistical metrics and was compared with GRACE score, the reference in Portuguese clinical practice. The new model originated a better balance between the sensitivity and specificity when compared with the GRACE, originating an accuracy improvement of approximately 22%.