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Among female subjects of reproductive age, polycystic ovarian syndrome (PCOS) is a common endocrine disorder that may be linked to a number of health risks for cardiovascular diseases (CVDs). The study aims to determine some CVD risk variables and how they relate to body mass index (BMI) in female subjects with PCOS. Fifty healthy women without PCOS (controls) and 90 women with PCOS between the ages of 18 and 45 were enrolled in the study. Standard methods were used to evaluate the serum sex hormones, lipid profile, troponin-I, highly sensitive C-reactive protein (hs-CRP), fasting blood glucose, and atherogenic indices. Compared to controls, the mean age of women with PCOS was substantially lower ($p<0.001$). The mean values of BMI, waist circumference, and hip were not significantly different from one another. While the cardiometabolic variables were higher in women with PCOS than in healthy subjects, no significant difference between obese/overweight and nonobese women with PCOS in terms of mean BMI, fasting blood glucose, insulin, atherogenic index of plasma (AIP), troponin-I, hs-CRP, luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol were observed. In PCOS-affected women, AIP ($r=0.712$, $p<0.001$), lipid accumulation product (LAP) ($r=0.764$, $p<0.001$), and hs-CRP ($r=0.666$, $p<0.001$) all showed positive correlations with BMI. Regardless of BMI status, there was an independent correlation between cardiovascular risk factors (CVRFs) and PCOS. This implies that regardless of a woman’s BMI, PCOS may increase her risk of CVD. Treatment combined with lifestyle modifications may be useful in lowering the risk of CVD in PCOS-afflicted Nigerian women. The finding suggests that PCOS itself, independent of weight, may increase the risk of heart disease. Nigerian women with PCOS are at increased risk of CVD, regardless of their BMI, and early detection, prevention, and treatment of CVRFs in women with PCOS is desirable.