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In intracellular mitogen-activated protein kinase (MAPK) cascades, it has been shown that signals can be propagated across the cell cytosol in the form of phosphoprotein waves arising from the bistable response of MAPK to active MAPK kinase. Without such a bistable response, however, they can not propagate into distant cell compartments, although a long positive feedback endows a mechanistically-distinct bistable response of MAPK to extracellular signal. Here we provide a compensate means that uses crosstalk between parallel identical pathways of MAPK cascades. For a spherical cell, we find that both unidirectional and bidirectional crosstalk with enhancement of phosphorylation can facilitate phosphoprotein signal propagation from the plasma membrane to the periphery of cell nucleus. Moreover, different shallow spatial gradients of biphosphorylated MAPK occur in the cytosol under different strengths of pathway interactions. These results suggest that crosstalk would be utilized by living organisms for spatial information transfer and cellular decision-making processing.

Singapore-Based Asian American Medical Group and Rich Tree Holdings Break Ground on Zhuhai-Singapore Life Science Park; Advanced Diagnostic and Wellness Medical Centre Will Bring World-Class Services to Southern China in 2018.

ASLAN Pharmaceuticals Opens China Office.

China to Improve Basic Science Research.

Chinese Scientists Edit Genes to Resist HIV in Embryos.

Scientists Find How Red Wine Compound Protects Heart.

Alliance for Stem Cell Technologies Established in Guangzhou.

China and Germany Keen to Deepen R&D Cooperation.

Study Unveils Novel Crosstalk Mechanism between Mitochondrial Translation and Cytoplasmic Translation.

China's Seed Haven Protects Endangered Plants.

Scientists Find that miR-155 Suppresses ErbB2-induced Malignant Transformation.

Nectar and Scent Secretion Patterns Reflect Floral Color Change Rhythm in Quisqualis indica.

SINGAPORE – Human Heart Tissue Grown from Stem Cells Improves Drug Testing.

UNITED STATES – Bioengineered Human Livers Mimic Natural Development.

UNITED STATES – New Cellular Target May Put the Brakes on Cancer’s Ability to Spread.

UNITED STATES – Does Consuming Low-Fat Dairy Increase the Risk of Parkinson’s Disease?

UNITED STATES – Memory Loss and Other Cognitive Decline Linked to Blood Vessel Disease in the Brain.

AUSTRALIA – Fabricating High Performance Nanohybrid Catalysts.

TAIWAN – US FDA Approves Zhaohe Cao-based Botanical Drug as an Investigational New Drug for Cancer Therapy.

KOREA – Distinguished Professor Sang Yup Lee Elected to the NAS.

Numerous crosstalk interactions between RNA-binding proteins (RBPs) and microRNAs (miRNAs) have been recently reported, unveiling the complexity and importance of gene expression modulation in health and disease. They control physiological processes such as stem cell maintenance, neuronal development or energetic metabolism, but are also responsible for pathological conditions, such as muscle waste and dystrophies, atherosclerosis, obesity and cancer. MiRNAs and RBPs are two of the well-studied post-transcriptional regulators and they may even reciprocally regulate themselves. MiRNAs can act on RBPs expression while RBPs modulate miRNA biogenesis, function and degradation. RBPs and miRNAs modulate mRNA expression at different levels, affecting their stability, splicing and translation efficiency through either competition for overlapping binding or modulation of mRNA structure by binding, but several other forms of interaction have been described. In this review, we will address the current bibliography regarding miRNA:RBP interactions and crosstalk events as well as their implications in health and disease.