Narrow Results

Objective: This study aims to explore the use of machine learning algorithms for predicting disease classification. Methods: An integrated algorithm (KPLSKELM) was proposed in this study. The algorithm employed kernel principal component analysis to transform the original data into a high-dimensional feature space, thereby enhancing its linear separability. It used the sparrow search algorithm (SSA) to optimize the weight matrix and parameters of the kernel extreme learning machine (KELM). The algorithm incorporated a Gaussian perturbation search mechanism to refine the population initialization strategy so as to mitigate the issues of poor convergence rate and susceptibility to local optima in the later SSA iterations. Lévy flight perturbations were introduced during the foraging search process of the sparrow population to guide the population in moving appropriate step sizes, thereby increasing the diversity of the spatial search. The proposed method was experimentally validated using a binary classification breast cancer dataset collected by Dr. William H. Wolberg from a Wisconsin hospital in the United States and a multiclass classification dataset of electrocardiographic recordings during childbirth. Multiple metrics were adopted to evaluate the classification performance. Results: The accuracy and F1_score of the KELM model remained relatively low across different percentages of the training set, although a recall of 1.0000 was consistently achieved. Both the SSA-improved KELM and the Lévy-improved SSA-optimized KELM algorithms exhibited better performance in terms of the comprehensive metric F1_score and improved with the increase in the percentage of the training set. The KPLSKELM model outperformed others in all metrics, with accuracy, precision, recall, and F1_score approaching or reaching the highest levels when using 90% of the training set. Conclusions: The proposed method demonstrated excellent performance in various disease prediction tasks, holding high practical application value. It provided a reference for further assisting clinicians in making more precise treatment decisions.

Diver’s disease is a complication that the human body suffers from after being in a high-pressure space and then quickly entering a low-pressure space. These pressures are very harmful for the tissues of the body, especially for the brain. Decompression sickness occurs when nitrogen bubbles up in the bloodstream, caused by staying underwater too long or surfacing too quickly. Decompression sickness symptoms usually appear with a delay after diving. By processing electroencephalography, information about neurophysiological disorders can be extracted precisely. Since the diagnosis of divers’ diseases has not been dealt with using a unique model, this paper deals with the diagnosis of brain abnormalities caused by diving. In this paper, an intelligent model using the electroencephalography of divers will be presented to diagnose the brain disorders. The proposed model based on the brain function can show the connections of the divers’ brain regions using cellular neural networks. First, the effective features are extracted from the signals, and then based on the proposed architecture based on the brain, the differences in the brain connections of divers compared to non-divers are expressed. The obtained results show that there are differences in intra-regional connections of some brain regions of divers including T7, T8, O1 and O2 ($p$ < 0.05) compared to nondivers.

Based on the pharmaco-physiology of the aminobisphosphonates, it could be speculated that bisphosphonates could induce not only the osteopetrotic bone disease because of their selective suppression of osteoclastic activity, but also could affect directly or indirectly the endocrine system, local factors, and also the bone metabolic turnover. Consequently, the bone fragility could be rather produced by long-term aminobisphosphonate therapy. Bisphosphonate-mediated bone disease was labeled by Odvina et al. in 2005 [Odvina CV, Zerwerth JE, Rao DS et al. Severely suppressed bone turnover; a potential complication of alendronate therapy. J Clin Endocrinol Metab90: 1294–1301, 2005.] as the "severely suppressed bone turnover (SSBT)" on the metabolic turnover basis. However, such definition could contain various drug-induced bone diseases, and did not indicate any particular condition, induced by the bisphosphonate. The term "SSBT" is thought not solely to be based on its histology, and seems rather a clinical term applicable to the various drug-induced bone diseases. Therefore, the current authors attempted to characterize the bisphosphonate-mediated bone disease on the basis of the combined image and histological studies, and finally concluded that the prolonged bisphosphonate therapy could produce an atypical osteomalacic bone disease. (osteosclerosis of osteomalacia) which leads to fragility fracture. It is puzzling as to why malacia rather than petrosis develops in the skeleton.

AUSTRALIA – Second-Generation Diagnostic Achieves 98% Accuracy in Detecting Early Stage Ovarian Cancers

AUSTRALIA – New Center Brings Australian and Chinese Researchers Together to Fight Infectious Diseases

AUSTRALIA – Co-developing New Treatment Guidelines for Melanoma

AUSTRALIA – Australia Leads World's First Global Effort to Improve Genetic Disorders Diagnosis

CHINA – China Bans Illegal Food Additives to Reinforce Food Safety Control

CHINA – China Steps Up Tighter Inspection in Food Safety

CHINA – WHO and China to Do More for Chinese with Hearing Impairment

CHINA – First TCM Drug for Arrhythmia

CHINA – First Human-Human Transmission of Tick-Borne Disease Reported in China

CHINA – Bird Flu Found in Chickens in Eastern China

CHINA – First Bird Flu Death Reported for 2009, No Bird-flu Outbreak

HONG KONG – Hong Kong Alerts New Bird Flu Outbreak

INDIA – India Also Confirmed Bird Flu Incidence

INDIA – India Plans 20 More Biotech Parks for Life Sciences Research

KOREA – An Economic Share in Medical Tourism Market

JAPAN – Brain Tissues Made from Stem Cells

NEW ZEALAND – Newly Merged Research Institute Leverage Greater Synergy

NEW ZEALAND – Kiwi's Green Plastic Well-Acclaimed in International Awards

NEW ZEALAND – Sea Sponge Indigenous to NZ Could Reduce Chemo Side Effects

PHILIPPINES – Ebola-Reston Virus Jumped Species

SINGAPORE – Human Sewage, the Potential Source of Clean Energy

SINGAPORE – No More Heart-stopping Incidents for Heart Patients

SINGAPORE – China Milk Products Get All-Clear from Singapore

SINGAPORE – Discovery of New Properties in Imidazolium Salts Yield Multi Applications

SINGAPORE – S'pore Ranked World's Most Prolific for Eye Research Per Capita

SINGAPORE – Outdoor Sun Reduces Incidence of Myopia in Children

TAIWAN – University Hospital in Taiwan Collaborates with Neuralstem

VIETNAM – Return of Bird Flu, Vietnam Runs High Risk of Human Infection

VIETNAM – Conjoined Twins Successfully Separated

VIETNAM – Rise in Off-Season Dengue Fever Cases

NORTH AMERICA – Epilepsy Drugs Prescription to Carry Suicide Risk Warning

NORTH AMERICA – U.S. Doctors Succeeded Near-total Face Transplant

NORTH AMERICA – Vaccinating Pacific Girls against Cervical Cancer

NORTH AMERICA – Manipulating Love and Emotions by Spray

EUROPE – Cambridge Pips Oxford in Research

EUROPE – Adapting Car Manufacturing Technology to Produce Synthetic Bone Implants

EUROPE – Dioxin-tainted Irish Pork Products Recalled

Chinese Physician Appointed to Lead Clinical Operations of MDS Pharma Services in Asia

Swiss to Helm Takeda Pharmaceuticals Asia Private Limited as New CEO

First Asian Honored Prestigious American Award

I²R's Researcher Selected as One of the Only Two Nokia Visiting Professors for 2009

International Business Honcho Appointed as New Country CEO for Siemens Singapore

Australian Scientists Reach Breakthrough in Stem Cell Research.

Breakthrough in Disease Management of Chikungunya Fever by Singapore Researchers.

MicroRNAs Lead to Formation or Suppression of Tumors? Singapore and US Scientists Share Results.

Singapore and South Korea to Invent More New Materials.

Asian Blood Cancer Patients Respond Better with a Lower Drug Dosage.

Safer Ethical Way to Make Human Stem Cells.

"Blushing" Response from Alcohol Drinking Signals Increased Cancer Risk Among East Asians.

Interview with Frost & Sullivan — Celebrating Best Practices in Healthcare.

Interview with InterSystems Corporation — Connecting Applications, Processes and People Intelligently.

Interview with Philips Healthcare — Excellence in Medical Imaging & Radiology.

Interview with Roche Diagnostics — Cutting-Edge Clinical Diagnostics.

Benitec MOU with Biomics Biotechnologies China.

Arkema & Aussie Chemeq Sign Manufacturing Cooperation Agreement.

AstraZeneca and Mental Health Research Institute in Australia Announce Collaboration to Improve Early Detection of Alzheimer's Disease.

Avexa Gets CSIRO Investment.

Living Cell Technologies' Encapsulated Choroid Plexus Cells May Be Used To Treat Hearing Loss.

Sundia MediTech Acquires Protein Folding Technology.

Beijing Cancer Hospital Introduces Fast and Precise RapidArc Radiotherapy Cancer Treatments.

Zydus Cadila and Karo Bio's Research Collaboration has Generated Promising Lead Compounds.

ICON Acquires Veeda Laboratories Limited.

Novavax-Cadila to Conduct Swine Flu Clinical Trials.

Axygen & Astellas form JV to Develop Protein Drugs.

Rexahn, KRICT to Develop Anti-Cancer Drugs.

Japan's Largest Pharmaceutical Firm Opens Regional HQ in Singapore.

Ultrasound-Mediated Gene Therapy - Philips and Glygenix Team Up.

Vietnam Healthcare - The Next Growth Frontier?

New Ultrasound System Could Lower Number of Biopsies.

AUSTRALIA – New Test Will Help Identify Viral Cattle Disease.

AUSTRALIA – Vision CRC Technology to Control Myopia.

AUSTRALIA – Living Skin for Burns Victims.

AUSTRALIA – IVF Clinic Develops Improved Screening.

AUSTRALIA – Glaucoma Affecting 150,000 Australians.

AUSTRALIA – Bionic Eye Design to be Unveiled.

AUSTRALIA – Australian Scientists in TB Drug Breakthrough.

CHINA – China Suffering Diabetes Epidemic: Report.

CHINA – Chinese Researchers Discover First Therapeutic Hepatitis B Vaccine in the World.

CHINA – In Annual Rite, Chinese Science Showered With Riches.

HONG KONG – Swine Flu's Got New Genes On.

INDIA – Apollo Hospitals to Conduct Research in Ayurveda.

INDIA – Project to Check Heart Disease in Corporates Launched.

INDIA – Indian Scientist Develops Low-cost Cancer Detector.

INDIA – Conjoined Twins Separated After a 14-hour surgery at Delhi hospital.

JAPAN – Genetically Modified Mosquitos may Help Fight Malaria.

SINGAPORE – NUHS to Partner Harvard.

SINGAPORE – S'pore Team Develops Mobile ECG Machine.

SINGAPORE – Novel Method to Produce Precise Medical Images for Detection of Diseases.

SINGAPORE – Singapore Got S$1.2 bn Investment in BMS in 2009.

SINGAPORE – Singapore and Sweden Institutes Ink Research Collaboration on Environmental Technologies.

SINGAPORE – Simple Test for Lung Patients.

TAIWAN – Taiwan, Japan Entities Team up on Research.

VIETNAM – HCM City Public Hospitals Run Out of Recognized Vaccines.

OTHER REGIONS — NORTH AMERICA – Researchers Seek Funding to Study How Climate Change Influenced Human Evolution.

OTHER REGIONS — EUROPE – A Blood Test to Detect Breast Cancer.

AUSTRALIA – Laser Method to Restore Sight an Aussie Miracle.

AUSTRALIA – Brain Estrogen Shows Promise as Schizophrenia Treatment.

AUSTRALIA – New Blood Test for Newborns to Detect Allergy Risk.

AUSTRALIA – UQ Wins $6.5 Million for Groundbreaking Research Projects.

CHINA – China: New HIV Model Suggests Killer T Cell for Vaccine.

CHINA – 17 Babies Injected with Expired Medicine.

CHINA – Substandard Human Rabies Vaccine Recalled.

CHINA – China Faces New Health Scare Over 'Bad Vaccines'.

INDIA – Artificial Blood Vessels Developed from Jatropha.

INDIA – India and Germany to Initiate Joint Research in Oncology, Regenerative Medicine, Neurosciences.

INDIA – Indian Scientists Decode TB Bacteria Genome.

INDIA – Nearly Half a Million Foreigners Throng India for Cheap Treatment.

INDIA – Transgenic Chicken for Therapeutic Use Developed.

JAPAN – Japan's Miyazaki Beef Threatened by Foot-and-Mouth Outbreak.

SINGAPORE – Number of Flu Cases Near Epidemic Levels.

SINGAPORE – $140m Expansion to Increase R&D Space at The Biopolis.

SINGAPORE – Singapore Scientists' Zebrafish Model for Parkinson's Disease an Important Step Closer to Drug Development for the Disease.

SINGAPORE – Painless, Cheaper Way to Diagnose Bladder Cancer.

SINGAPORE – Fujitsu Establishes its First Biomedical Research Laboratory in Singapore.

SINGAPORE – A*Star, MRC Grant $4.5m for Six Research Projects.

SINGAPORE – Singapore Scientists Exploit p53 to Improve Cancer Treatment.

TAIWAN – Taiwan Scientists Identify Keys to Bipolar Disorder.

NORTH AMERICA – First Prostrate Cancer Vaccine a Major Breakthrough.

Benitec Limited Granted Hepatitis C RNA Interference Patent in US.

HUYA Bioscience International and China Medical City Forge Alliance.

Chindex, Fosun Pharma Form Joint Venture.

Daiichi Sankyo and Ranbaxy to Integrate New Drug Research and Development System.

TAKE Solutions and Reliance Life Sciences Enter Strategic Alliance.

Veeda Oncology Announces $8.4 million in New Business.

Medicago signs Vaccine MOU with PT Bio Farma.

Kyowa Hakko Kirin to Enter Out-licensing Agreement with Biovail.

Sosei to Acquire Activus Pharma.

Takeda to Expand Operations in South Korea.

SymBio and Cephalon Sign License Agreement.

Quintiles Announces Clinical Research Partnership with the University Malaya Medical Centre.

Roche's New DNA Sequencer Opens Innovation in Genomic Research.

Dow Microbial Control Academy Showcases Industrial Leadership and Expertise.

AUSTRALIA – New Therapy could Restore Mobility in Stroke Victims.

AUSTRALIA – Sugar as Bad as Fat.

AUSTRALIA – Scientists Uncover Cancer-fighting "Death" Protein.

AUSTRALIA – Shrinking Brain in Dementia Prompts Overeating.

AUSTRALIA – New Monitoring System for Mosquito-Borne Disease.

AUSTRALIA – Australian Researcher Finds Radical Technique to Save MAS Babies.

AUSTRALIA – Austrian Scientists Discover Enzyme Function in Cancer.

CHINA – Domestic Dengue Fever Cases Breaks 1,000.

CHINA – China Experts Design Gel to Protect Women from HIV.

INDIA – India, South Africa to Team up on HIV Vaccine Research.

MALAYSIA – Malaysia to use Lab Mosquitoes to Fight Dengue

NEW ZEALAND – Plant Derived Foods can Keep us Feeling Full.

SINGAPORE – Singapore Hosts First "Decade of the Mind" Conference in Asia and Expands Efforts in Brain & Cognition Research.

SINGAPORE – Drugs May Replace Chemo in Leukemia Therapy.

SINGAPORE – Singapore Scientists First to Perform Genome-Wide study of Human Stem Cells.

SINGAPORE – Singapore Babies in Waste-disease Trial.

SINGAPORE – New Technology a Shot in the Arm for Biofuels.

SINGAPORE – S$3.7 Billion for Singapore Biomedical Sciences R&D.

TAIWAN – Medical Tourism Booms in Taiwan.

OTHER REGIONS — EUROPE – Gene that Triggers Human Cancer Identified.

OTHER REGIONS — EUROPE – Painfully Potent Pepper.

OTHER REGIONS — NORTH AMERICA – 2 Dads and No Mum make 10 Mice.

Ocular Toxoplasmosis.

International Conference & Exhibition of the Modernization of Chinese Medicine & Health Products (ICMCM) - Annual Pivotal Event for Global Chinese Medicine Industry.

INDONESIA – Biomed Analysis: Indonesia needs a central science fund.

KOREA – Agilent Technologies helps City of Daegu and Daegu Gyeongbuk Institute of Science and Technology search for biomarkers for neurological diseases.

SINGAPORE – New S$6.5m facility at NTU by SCELSE and Carl Zeiss to boost used water treatment and environmental life sciences engineering research in Singapore.

SINGAPORE – Chugai expands in Singapore with opening of second satellite research institute.

SINGAPORE – Rising Above the Present into the Next-Generation.

SINGAPORE – Austrianova Singapore announces new pancreatic cancer models.

SINGAPORE – IBN and Fortis Colorectal Hospital establish tissue bank for colorectal cancer research.

SINGAPORE – Electronic medical records progress from an enterprise-centric solution to a customer-specific application, finds Frost & Sullivan.

SINGAPORE – Global perspectives on Health IT from Harvard Medical School thought leader, Dr Blackford Middleton.

AUSTRALIA – World's first fluorescent flowers.

UNITED KINGDOM – AbD Serotec introduces bovine and ovine Dendritic Cell Growth Kits and antibodies.

USA – Medicago Successfully Completes the Production of More Than Ten Million Doses of H1N1 VLP Influenza Vaccine in One Month.

USA – Research validates BioNano genomics' mapping platform for complex human genome analysis.

USA – Nine population strategies to stop short of 9 billion.

USA – Virtual science libraries to be launched in Central Asia.

USA – Vaginal ring may help reduce HIV infections.

AUSTRALIA – Successful FDA end-of-Phase-2 for Hatchtech head lice product DeOVO^™

AUSTRALIA – Senz Oncology secures seed funding for promising cancer drug.

AUSTRALIA – Geneworks develops DNA barcodes for international security.

INDIA – Stress hormones: Good or Bad for Posttraumatic Stress Disorder risk?

SINGAPORE – New study shows fertility knowledge gaps may exacerbate Singapore's declining birth rate challenge.

SINGAPORE – World's first wearable robotic device for stroke rehabilitation comes to Singapore.

SRI LANKA – Conflicting reports highlight scientific data gaps in Sri Lanka's chronic kidney disease.

EUROPE – InDex Pharmaceuticals strengthens IP position for Kappaproct.

EUROPE – Novozymes and Terranol to market advanced biofuel yeast.

EUROPE – The world's first (official) biosimilar antibody goes to… Rheumatoid Arthritis.

USA – MRI reveals brain's response to reading.

USA – Novozymes partner Chemtex receives USDA commitment to build advanced biofuels plant in United States.

USA – Fossil fuel and renewable energy subsidies on the rise.

Biotechnology unveils secrets of Chinese medicine.

Climate change a mixed blessing for wheat, say experts.

NTOU identified germ cells and somatic cells in coral bodies for the first time in the world.

Researchers tabulate disturbing changes and disappearance in biodiversity in Southern Taiwan coral reefs over last 26 years.

NCKU research team discovers new complex in treating cancer.

Chinese scientists successfully crack the genome of diploid cotton.

Taiwan's healthcare market boosted by aging population.

Researchers develop mouse model of common motor neuron disease pinpointing TDP-43 protein as likely cause.

Fosun Pharmaceutical and Shanghai drugs open innovation model.

QIAGEN gains SFDA approval to market careHPV Test.

AstraZeneca's heart drug wins approval.

SIMM explores a novel cationic core-shell lipo-nanoparticles for ocular gene drug delivery.

TaiGen and TTY Biopharm jointly develop and commercialize a novel topoisomerase I inhibitor for cancer treatment.

iHuman Institute inauguration held.

Sihuan Pharmaceutical collaborates with NeuroVive to develop two innovative cardio-cerebral vascular products.

PerkinElmer acquires China-based infectious disease diagnostics company.

AUSTRALIA – Well-known antibiotic amoxycillin found to be ineffective cough treatment.

AUSTRALIA – Bring the noise: has technology made us scared of silence?

INDIA – Biocon receives marketing authorization for novel biologic itolizumab for psoriasis.

ISRAEL – Aspireo reports Somatoprim Phase Ib interim data.

JAPAN – Daiichi Sankyo and Amplimmune announce strategic alliance to develop AMP-110 therapy for autoimmune disease.

JAPAN – Eisai signs agreement with Epizyme and Roche Molecular Systems to develop companion diagnostic.

THE PHILIPPINES – Asia-Pacific Analysis: The growth of stem-cell therapy.

THE PHILIPPINES – Is the world ready for scientific diplomacy?

UNITED KINGDOM – ARIAD and the U.K. National Cancer Research Institute to collaborate on SPIRIT 3 clinical study.

UNITED KINGDOM – Vision research collaboration on novel treatment for wet age-related macular degeneration.

UNITED STATES – Reducing medical mistakes: Two recently published studies support the use of DNA testing on biopsy samples to prevent misdiagnoses.

UNITED STATES – CoDa Therapeutics reports positive results from Phase IIb Study of NEXAGON® in chronic venous leg ulcers.

UNITED STATES – Inovio Pharmaceuticals to initiate clinical trial for its hepatitis C therapeutic vaccine later this year.

UNITED STATES – Jolt to brain eases pain without drugs.

UNITED STATES – Can a new vaccine prevent colon cancer?

UNITED STATES – Immunovaccine's DPX-Survivac produces sustained, dose related immune responses in Phase I ovarian cancer study.