Keyword: Dual-functional Small Molecule : Search

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Search name	Searched On	Run search
Keyword: Dual-functional Small Molecule (1)	15 Mar 2025	Run
[Author: Chen, Shen-Yuan] AND [Keyword: Taiwan] (3)	15 Mar 2025	Run
[Author: Chang, Hung-Hao] AND [Keyword: Taiwan] (1)	15 Mar 2025	Run
Keyword: Alkali-metal Atoms (1)	15 Mar 2025	Run
[Author: Li, Xiang-Yang] AND [Keyword: Spanner] (2)	15 Mar 2025	Run

articleNo Access
Selective hydroxylation of naphthalene using the H₂O₂-dependent engineered P450BM3 driven by dual-functional small molecules
- Zhifeng Chen,
- Jie Chen,
- Nana Ma,
- Haifeng Zhou, and
- Zhiqi Cong
Journal of Porphyrins and Phthalocyanines21 Aug 2018
Preview Abstract
We herein report the H₂O₂-dependent selective hydroxylation of naphthalene catalyzed by engineered P450BM3 with the assistance of dual-functional small molecules (DFSMs). The mutation at position 268 significantly improved the hydroxylation activity of P450BM3, which is quite different from those engineered P450BM3 peroxygenases and NADPH-dependent P450BM3 mutants previously reported, implicating the unique role of the residue at position 268. This study provides a potential approach to develop the practical hydroxylation biocatalyst of P450s for aromatic hydrocarbons using the DFSM-facilitated P450BM3-H₂O₂ system.

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