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The history and development of reproductive genetics span centuries of scientific exploration and technological innovation. Today, the importance of offspring health and further understanding of the relevant molecular mechanisms and interdisciplinary knowledge have led to significant advancements, which are gradually appearing in clinical settings. However, whether this rapid progress in reproductive genetics could lead to technical, ethical, and economic problems warrants evaluation. This brief review introduces a range of approaches to reproductive genetics, from the earliest to the most recent, and discusses future concerns regarding the large-scale use of emerging reproductive genetic tools.