Narrow Results

In this chapter, the humane use of animals in surgical research is described, with reference to Russell and Burch's The Principles of Humane Experimental Technique (1992) — commonly known as the 3R's of replacement, reduction, and refinement — as well as the ethical need for researchers to justify the experiment and take responsibility for the well-being of animals in their care. The basic role of animal ethics committees is also discussed. The chapter then describes in practical terms the preparation of the experimental animal for surgery; the techniques for anesthesia, including knock-down, intubation, and maintenance; and the drugs used for premedication before anesthesia, maintenance of anesthesia, and, most importantly, pre-emptive and postoperative pain relief. The monitoring of the experimental animal under anesthesia and during recovery is also discussed.