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This research focuses on generating the plastic collapse load boundaries of a cylindrical vessel with a radial nozzle via employing three different plastic collapse load techniques. The three plastic collapse load techniques employed are the plastic work curvature (PWC) criterion, the plastic work (PW) criterion, and the twice-elastic-slope (TES) method. Mathematical based determination of plastic collapse loads is presented and employed concerning both the PWC and the PW criteria. A validation study is initially conducted on a pressurized 90-degree pipe bend structure subjected to in-plane closing bending via finite element analyses along with an elaborate explanation of the mathematical approaches for determining the plastic collapse loads via the PWC and the PW criteria. Outcomes of the validation study revealed very good outcomes for the three techniques. Accordingly, the aforementioned three techniques are utilized to determine the plastic collapse load boundaries of a pressurized cylindrical vessel/nozzle structure subjected to in-plane (IP) and out-of-plane (OP) bending loadings applied on the nozzle one at a time. The TES method revealed considerate limitations when applied within the medium to the high internal pressure spectra. It is shown that both the PWC and the PW criteria outperform the TES method in computing the plastic collapse loads. The vessel/nozzle structure revealed relatively higher plastic collapse moment boundaries under IP bending as compared to OP bending. Conclusively, methodical steps are devised for determining the plastic collapse loads via the PWC and the PW criteria for the ease of systematic application on pressurized structures in general.