Narrow Results

Low hemolysis is an important factor for axial blood pumps that has been used in patients with heart failure. The structure of impellers plays a key role in the hemolytic properties of axial blood pumps. Axial blood pumps with various structure impellers exhibit different hemolytic characteristic. In the present study, we aimed to investigate the type of impellers structures in axial blood pumps that contain the best low hemolytic properties. Also, it is expensive and time-consuming to validate the axial blood pump's hemolytic property by in vivo experiments. Therefore, in the present study, the numerical method was applied to analyze the hemolytic property in a blood pump. Specifically, the hemolysis of the pump was calculated by using a forward Euler approach based on the changes in shear stress and related exposure times along the particle trace lines. The different vane structures and rotational speed that affect hemolysis were analyzed and compared. The results showed that long–short alternant vanes exhibited the best hemolytic property which could be utilized in the optimization design of axial blood pumps.

Low hemolysis and hydraulic performance are important factors for an axial blood pump, which have been transplanted in patients with heart failure (HF). The distance and clearance between impeller and diffuser play a key role in hemolytic properties and hydraulic performances of axial blood pumps that were developed by our group inspired by the design features of HeartMate II. In the present study, we aimed to investigate the appropriate distance and clearance between impellers and diffusers of axial blood pumps, which contains the best low hemolytic property and hydraulic performance using the computational fluid dynamics (CFDs) approach. Specially, the hemolysis of the pump was calculated by using two different empirical power-law hemolytic blood damage models with two sets of parameters. The two hemolytic blood damage models with two sets of parameters were analyzed and compared. Further, the different distances and clearances between impellers and diffusers that affect hemolytic and hydraulic characteristics were also analyzed. The results showed that the pump with distance of 2mm and clearance of 0.2mm between impeller and diffuser exhibited the best hemolytic property and better hydraulic performance.

Hemolysis in blood-contacting devices severely affects the health of users, and computation fluid dynamics (CFD) simulation is a crucial method for hemolysis analysis. Medical equipment has high requirements for simulation accuracy. Modification of the turbulence model is one of the most effective ways to improve efficiency. In this study, we designed nozzle models to simulate hemolytic shear flow, varying the degree of shear flow through different nozzle orifice sizes. The study acquires microscopic flow results through Particle Image Velocimetry (PIV) experiments, and the Sparlart–Allmaras (S–A) model was modified based on the experimental results. In the study, we obtained the influence characteristics of the model coefficients on the simulation results and completed the accuracy correction. The results showed that the model coefficient $c_{b1}$ has the most significant effect on the simulation results. Correcting $c_{b1}$ to about 200% of the standard value can significantly improve the simulation accuracy, and the high shear flow intensity corresponds to a slightly lower correction value. The model modification eliminates the simulation error in the high-speed area, and the comparison results show that it is superior to the standard turbulence model.