We study a mathematically rigorous derivation of a quantum mechanical Hamiltonian in a general framework. We derive such a Hamiltonian by taking a scaling limit for a generalization of the Nelson model, which is an abstract interaction model between particles and a Bose field with some internal degrees of freedom. Applying it to a model for the field of the nuclear force with isospins, we obtain a Schrödinger Hamiltonian with a matrix-valued potential, the one pion exchange potential, describing an effective interaction between nucleons.