Let D be an integral domain with quotient field K, R be an overring of D, X be an indeterminate over R and E be a subset of K. We consider the ring of D-valuedR-polynomials onE, denoted by IntR(E,D), formed by the polynomials f∈R[X] such that f(a)∈D for each a∈E, that is, IntR(E,D):={f∈R[X]:f(E)⊆D}. In this paper, we study localization properties, local freeness and faithful flatness of IntR(E,D) over various classes of locally essential domains. In particular, we extend some known results to more general settings.