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Texaphyrins: a new approach to drug development

TARAK D. MODY

Pharmacyclics, Inc., 995 East Arques Avenue, Sunnyvale, CA 94085, USA

Corresponding author, Pharmacyclics, Inc., 995 East Arques Avenue, Sunnyvale, CA 94086, USA.

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and

JONATHAN L. SESSLER

Department of Chemistry & Biochemistry, University of Texas at Austin, Austin, TX 78712, USA

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https://doi.org/10.1002/jpp.326Cited by:64 (Source: Crossref)

Abstract

The texaphyrins are prototypical metal-coordinating expanded porphyrins. They represent a burgeoning class of pharmacological agents that show promise for an array of medical applications. Currently, two different water-soluble lanthanide texaphyrins, namely motexafin gadolinium (Gd-Tex, 1) and motexafin lutetium (Lu-Tex, 2), are involved in multi-center clinical trials for a variety of indications. The first of these agents, XCYTRIN^® (motexafin gadolinium) Injection, is being evaluated as a potential X-ray radiation enhancer in a randomized Phase III clinical trial in patients with brain metastases. The second, in various formulations, is being evaluated as a photosensitizer for use in: (i) the photodynamic treatment of recurrent breast cancer (LUTRIN^® Injection; now in Phase IIb clinical trials); (ii) photoangioplastic reduction of atherosclerosis involving peripheral and coronary arteries (ANTRIN^® Injection; now in Phase II and Phase I clinical trials, respectively); and (iii) light-based age-related macular degeneration (OPTRIN™ Injection; currently under Phase II clinical evaluation), a vision-threatening disease of the retina. In this article, these developments, along with fundamental aspects of the underlying chemistry are reviewed.

Keywords:

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