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The parallelization of a structurally inhomogeneous Metropolis Monte Carlo particle/ potential problem was studied in an application to solvent clusters. The program was ported to a small parallel-processor system consisting of five T800–20 transputers. Different topologies are discussed. The optimum topology depends on the size of the computational problem; for our problem size it is a modified tree structure. Benchmarks are given for a transputer farm, and compared with results obtained on various scalar and vector processors.