Digital disruptions are substantially impacting businesses and reshaping our economy worldwide, attracting increasing attention in research and practice. However, research lacks theoretical framing and understanding of the emergence, development, and impact of digital disruption. This study analyses and structures the fragmented knowledge on digital disruption by means of a systematic literature review, identifying five relevant key dimensions, i.e., disruption characteristics, market factors, organisational factors, value constellation, and impact/outcomes. Based on this analysis and classic disruption theory, we develop a theory-informed integrative framework, proposing nine relevant layers of digital disruption and deriving corresponding theoretical propositions for future research. The study makes an initial contribution towards theory development and a comprehensive understanding of the digital disruption concept. It may serve as the starting point for further theory development and a guiding scheme for managers on how to create or deal with digital disruption.