This paper investigates the dissipative Casson ternary hybrid nanoflow comprising Ag, Cu, and MoS2 nanocomposite, over a flat plate. Incorporating the thermal source, varying temperature, and concentration provides the required novelty of the study. The physical flow model has been computationally resolved using the Bvp4c approach, after the transformation of the system of PDEs into coupled ODEs. The effects of various parameters on the velocity, temperature, mass distribution profiles, rate of shear stress, Nusselt number, and Sherwood number are shown in figures and tables. The thermo transposition rate in Newtonian, hybrid Newtonian, Casson, and Casson hybrid Newtonian fluids increases by 83%, 115%, 152%, and 183%, respectively, with the enhancement of the dissipation effect. Furthermore, the Sherwood coefficient increases by 31% for each of the four fluid types, while the variable mass index measurement improves. The results indicate a significant advancement in bio-nanofluid dynamics, presenting considerable prospects for optimizing heat transfer in bioengineering. An important concordance between the present investigation and the prior one has also been shown.