This paper aims to study the convective heat transfer behavior of aqueous suspensions of nanoparticles flowing through a horizontal tube heated under constant heat flux condition. Consideration is given to the effects of particle concentration and Reynolds number on heat transfer enhancement and the possibility of nanofluids as the working fluid in various heat exchangers. It is found that (i) significant enhancement of heat transfer performance due to suspension of nanoparticles in the circular tube flow is observed in comparison with pure water as the working fluid, (ii) enhancement is intensified with an increase in the Reynolds number and the nanoparticles concentration, and (iii) substantial amplification of heat transfer performance is not attributed purely to the enhancement of thermal conductivity due to suspension of nanoparticles.