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This chapter discusses the challenges arising for emergency logistics as a result of natural disasters as well as the empirical and quantitative approaches to a successful management of supply chain (SC) disruptions. In the first part, examples of recent natural catastrophes, their impact, and recovery measures are analyzed. In the second part, existing literature and examples of recent disasters are reviewed regarding the qualitative frameworks for SC disruption management and quantitative approaches to mitigate disruptions, and allow for recovery. The third part of this chapter is devoted to the critical analysis of the existing practices and methods, and elaborates on the improvement recommendations. In the fourth part, existing quantitative methods for disaster logistics are analysed. The fifth section is devoted to the best practice analysis in SC disruption management. The chapter is concluded by a summary and an outlook.