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Periodontal disease is an oral disease that has a high incidence worldwide, and it is considered the leading cause of tooth loss in adults. This condition is characterized by an infectious disease, painless and slowly progressive, being one of the main etiological agents Porphyrormonas gingivalis bacteria. This article analyzes the antibacterial activity of methanol extracts in different parts of the plant Azadirachta indica (A. Juss) planted in the northeastern region of Mexico, and currently used empirically in the development of toothpastes used in the people of this region. In some of the extracts tested were more active on P.gingivalis leaf, it shows more inhibition hales that tell us that the extracts of Neem afected the bacterial activiy. The data obtained from this analysis will be crucial to assess the feasibility and safety of its therapeutic use in humans.