Let Sn denote the symmetric group of degree n with n ≥ 3, S = { cn = (1 2 ⋯ n), c−1n, (1 2)} and Γn = Cay(Sn, S) be the Cayley graph on Sn with respect to S. In this paper, we show that Γn (n ≥ 13) is a normal Cayley graph, and that the full automorphism group of Γn is equal to Aut(Γn) = R(Sn) ⋊ 〈Inn(ϕ) ≅ Sn × ℤ2, where R(Sn) is the right regular representation of Sn, ϕ = (1 2)(3 n)(4 n−1)(5 n−2) ⋯ (∊ Sn), and Inn(ϕ) is the inner isomorphism of Sn induced by ϕ.