Narrow Results

Adaptive optics (AO) and optical coherence tomography (OCT) are powerful imaging modalities that, when combined, can provide high-resolution, 3-D, in vivo images of the retina. We will discuss general techniques for characterizing a vision science AO system, and we will describe the results of applying these techniques to measure the residual wavefront errors for the UC Davis AO-OCT system. Careful characterization of the AO system will lead to improved performance and inform the design of future systems.

Optical coherence tomography angiography (OCTA) has emerged as an advanced invivo imaging modality, which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among others. Based on the high numerical aperture (NA) probing lens and the motion-corrected algorithms, a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5 μm to 10 μm in diameter. As OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries, here we present a review on the latest techniques for the dynamic flow imaging. Studies on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.