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The vital factors which can facilitate the development of Startups and Small and Medium-Sized Enterprises (SMEs) in markets are the appropriate regulatory and policy frameworks. However, there is a difference in the frameworks which may contribute to different levels of development of startups and SMEs in different countries. This chapter thus focuses on the comparative study of the frameworks of selected countries to display their possible challenges in those countries. The chapter shows that governments in Japan, Republic of Korea, Malaysia, and Thailand adopt different regulatory frameworks which help stimulate the creation of startups and SMEs. It provides comparisons of the frameworks in those four countries, and also presents that there are challenges from these regulatory frameworks for startups and SMEs developing there.