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The emergence of the novel severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) Coronavirus resulted in a global pandemic due to its nature of rapid transmission and variable severities that facilitated its spread worldwide. Correspondingly, owing to advances in molecular technologies, information on this virus is generated at an unprecedented pace. Since the onset of the pandemic, multiple high-throughput “omics” analyses — including transcriptomics and proteomics of different viral infection models — have been made readily available to the research and wider community. The availability and ability to rapidly generate these data facilitate the deciphering of virus–host interactions during SARS-CoV-2 infection — thus enhancing understanding of the viral transmission, host susceptibility, pathogenesis, viral evolution, and disease complications. Such information is vital for eventual applications towards biomarker and treatment discovery against Coronavirus disease 2019 (COVID-19), and can serve as useful models for future pandemic responses.