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Region of interest (ROI) is the most important part of an image that expresses the effective content of the image. Extracting regions of interest from images accurately and efficiently can reduce computational complexity and is essential for image analysis and understanding. In order to achieve the automatic extraction of regions of interest and obtain more accurate regions of interest, this paper proposes Optimized Automatic Seeded Region Growing (OASRG) algorithm. The algorithm uses the affinity propagation (AP) clustering algorithm to extract the seeds automatically, and optimizes the traditional region growing algorithm by regrowing strategy to obtain the regions of interest where target objects are contained. Experimental results show that our algorithm can automatically locate seeds and produce results as good as traditional region growing with seeds selected manually. Furthermore, the precision is improved and the extraction effect is better after the optimization with regrowing strategy.