We consider a locally flat 2-sphere embedded in S2 × S2, which is referred to as a 2-knot in S2 × S2, and we study the problem whether a 2-knot in S2 × S2 is determined by its exterior. In this paper, we show that for almost homology classes ξ, 2-knots in S2 × S2 representing ξ are determined by their exteriors.