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Monochromatic infrared energy (MIRE) or anodyne therapy has been shown to increase nitric oxide level locally and increase the local circulation at the site it is applied. Diabetic foot ulcers may take a long time to heal. Chronic diabetic foot ulcers resistant to conventional treatment with daily dressings could be treated with anodyne therapy on an outpatient basis. The authors showed successful application of their modality of treatment in four chronic diabetic foot ulcers which failed to heal with conventional methods.