Machine learning (ML) is a branch of computer science that is rapidly gaining popularity within the healthcare arena due to its ability to explore large datasets to discover useful patterns that can be interepreted for decision-making and prediction. ML techniques are used for the analysis of clinical parameters and their combinations for prognosis, therapy planning and support and patient management and wellbeing. In this research, we investigate a crucial problem associated with medical applications such as autism spectrum disorder (ASD) data imbalances in which cases are far more than just controls in the dataset. In autism diagnosis data, the number of possible instances is linked with one class, i.e. the no ASD is larger than the ASD, and this may cause performance issues such as models favouring the majority class and undermining the minority class. This research experimentally measures the impact of class imbalance issue on the performance of different classifiers on real autism datasets when various data imbalance approaches are utilised in the pre-processing phase. We employ oversampling techniques, such as Synthetic Minority Oversampling (SMOTE), and undersampling with different classifiers including Naive Bayes, RIPPER, C4.5 and Random Forest to measure the impact of these on the performance of the models derived in terms of area under curve and other metrics. Results pinpoint that oversampling techniques are superior to undersampling techniques, at least for the toddlers’ autism dataset that we consider, and suggest that further work should look at incorporating sampling techniques with feature selection to generate models that do not overfit the dataset.
