In this paper, the effect of heat and mass transfer on particle–fluid suspension due to peristaltic motion is examined with of slip effects. The governing equations of fluid phase and particulate phase for Casson fluid model with embedded particles are interpreted under the approximation of long wavelength and neglecting the inertial forces. The obtained coupled resulting partial differential equations are solved analytically and an exact form of solutions are conferred. The impact of various sundry parameters are plotted and discussed for velocity, temperature and concentration distribution for both fluid and particle phase. Numerical solution is evaluated for pressure rise along the whole channel. The present analysis reveals various interesting behavior that warrant further analysis on various Newtonian and non-Newtonian fluids. In the present flow problem, the influence of slip represents opposite attitude on the walls of the channel whereas due to the impact of particle volume fractions, the velocity of the fluid diminishes along the whole length of the channel.