During the development of the theory of slice regular functions over the real algebra of quaternions ℍH in the last decade, some natural questions arose about slice regular functions on the open unit ball 𝔹B in ℍH. This work establishes several new results in this context. Along with some useful estimates for slice regular self-maps of 𝔹B fixing the origin, it establishes two variants of the quaternionic Schwarz–Pick lemma, specialized to maps 𝔹→𝔹B→B that are not injective. These results allow a full generalization to quaternions of two theorems proven by Landau for holomorphic self-maps ff of the complex unit disk with f(0)=0f(0)=0. Landau had computed, in terms of a:=|f′(0)|, a radius ρ such that f is injective at least in the disk Δ(0,ρ) and such that the inclusion f(Δ(0,ρ))⊇Δ(0,ρ2) holds. The analogous result proven here for slice regular functions 𝔹→𝔹 allows a new approach to the study of Bloch–Landau-type properties of slice regular functions 𝔹→ℍ.