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Nanostructured CuO has been successfully synthesized via Thermal decomposition method at 700∘C. Prepared CuO was characterized using IR spectra, X-ray diffraction (XRD) and scanning electron microscopy (SEM). IR spectra confirm the metal–oxygen bonding in these nanoparticles. The XRD pattern confirms a single-phase crystalline nature of the nanoparticles. The synthesized CuO was demonstrated as an efficient catalyst in degradation of Rhodamine B in the presence of light through oxidation. More than 93% of the Rhodamine B dye was degraded after 150min. It was observed that photocatalytic degradation of dyes follows pseudo-first-order kinetics. A tentative mechanism has also been proposed for the photocatalytic degradation of dyes in the presence of copper oxide semiconductor.