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  • articleNo Access

    IN VIVO CHARACTERIZATION OF THE MUSCLE VISCOELASTICITY IN PASSIVE AND ACTIVE CONDITIONS USING MULTIFREQUENCY MR ELASTOGRAPHY

    This study aims to develop a viscoelastic database for muscles (VM: vastus medialis and Sr: sartorius) and subcutaneous adipose tissue with multifrequency magnetic resonance elastography (MMRE) coupled with rheological models. MMRE was performed on 13 subjects, at 70-90-110 Hz, to experimentally assess the elastic properties (μ) of passive and active (20% MVC) muscles. Then, numerical shear modulus (μ) and viscosity (η) were calculated using three rheological models (Voigt, Zener, Springpot). The elastic properties, obtained with the Springpot model, were closer to the experimental data for the different physiological tissues (μSpringpot_VM_Passive = 3.67 ± 0.71 kPa, μSpringpot_Sr = 6.89 ± 1.27 kPa, μSpringpot_Adipose Tissue = 1.61 ± 0.37 kPa) and at different muscle states (μSpringpot_VM_20%MVC = 11.29 ± 1.04 kPa). The viscosity parameter increased with the level of contraction (η_VM_Passive_Springpot = 4.5 ± 1.64 Pa.s versus η_VM_20%MVC_Springpot = 12.14 ± 1.47 Pa.s) and varied with the type of muscle. (η_VM_Passive_Springpot = 4.5 ± 1.64 Pa.s versus η_Sr_Springpot = 6.63 ± 1.27 Pa.s). Similar viscosities were calculated for all tissues and rheological models. These first physiologically realistic viscoelastic parameters could be used by the physicians to better identify and monitor the effects of muscle disorder, and as a database for musculoskeletal model.

  • articleNo Access

    PARAMETER ANALYSIS OF 2D COCHLEAR MODEL AND QUANTITATIVE RESEARCH ON THE TRAVELING WAVE PROPAGATION

    The traveling wave is the most important phenomenon in cochlear macromechanics. The behaviors of the traveling wave that greatly alter the auditory discrimination, are tightly related with the mechanical properties of the basilar membrane (BM) and its surrounding lymph. As an addition to the blanks of related researches, this paper focuses on some of the key parameters that affect the cochlear response most: the BM stiffness, damping parameters and the fluid viscosity. The influence of these parameters on the traveling wave is discussed, based on our former developed 2D finite element hydrodynamic cochlear model. Moreover, the traveling wave velocity and its transmitting time are calculated based on the simulating results. Although generally a rapid fall of the velocity from the cochlear base to the characteristic frequency (CF) location is confirmed, our quantitative analysis also indicates the traveling wave velocity may be both location and frequency dependent.

  • articleNo Access

    INFLUENCE OF PARTICLE SIZE ON DENSITY, ULTRASONIC VELOCITY AND VISCOSITY OF MAGNETITE NANOFLUIDS AT DIFFERENT TEMPERATURES

    Nano01 Dec 2014

    The influence of particle size on density, ultrasonic velocity and viscosity of magnetite nanofluids have been determined at (298.15 K, 303.15 K, 308.15 K and 313.15 K). Two different sized nanoparticles (commercially procured D = 20–30 nm and synthesized D = 9 ± 3 nm in the laboratory by co-precipitation method) were dispersed in a citric acid base fluid. The desired parameters have been experimentally determined by loading different concentrations of nanoparticles. It has been found that the influence of particle size and temperature on measured physical parameters (density, ultrasonic velocity and viscosity) is not negligible and can also be taken into account in any practical application. The analyzed physical parameters can describe qualitatively and quantitatively the particle size distribution of nanofluids at a specific temperature. Results are interpreted in terms of particle–particle and particle–fluid interactions.

  • articleNo Access

    Investigation of Thermal Conductivity and Viscosity of Al2O3/Water Nanofluids Using Full Factorial Design and Utility Concept

    Nano01 Aug 2016

    In the present study, the effect of particle concentration, particle diameter and temperature on the thermal conductivity and viscosity of Al2O3/water nanofluids was investigated experimentally using design of experiment approach (full factorial design). Variables were selected at two levels each: particle concentration (0.1–1%), particle diameter (20–40nm) and temperature (10–40C). It was observed that the thermal conductivity of the Al2O3/water nanofluids increases with increasing concentration and temperature and decreases with increase in particle diameter, while viscosity increases with increasing particle diameter. Results showed that the interaction effect of concentration and temperature also has significant effect on the thermal conductivity of Al2O3/water nanofluids. For viscosity, the interaction of particle diameter and temperature was important. Utility concept was used to optimize the properties collectively for better heat transfer performance. The optimal combination for high thermal conductivity and low viscosity was obtained at higher level of particle concentration (1%), lower level of particle diameter (20nm) and higher level of temperature (40C). At this condition the increment in thermal conductivity and viscosity compared to base fluid was 11.51% and 6.37%, respectively.

  • articleFree Access

    DEVELOPMENT OF A GENERIC ULTRASOUND VIBRO-ACOUSTIC IMAGING PLATFORM FOR TISSUE ELASTICITY AND VISCOSITY

    Tissue elasticity and viscosity are always associated with pathological changes. As a new imaging method, ultrasound vibro-acoustic imaging is developed for quantitatively measuring tissue elasticity and viscosity which have important significance in early diagnosis of cancer. This paper developed an ultrasound vibro-acoustic imaging research platform mainly consisting of excitation part and detection part. The excitation transducer was focused at one location within the medium to generate harmonic vibration and shear wave propagation, and the detection transducer was applied to detect shear wave at other locations along shear wave propagation path using pulse-echo method. The received echoes were amplified, filtered, digitized and then processed by Kalman filter to estimate the vibration phase. According to the phase changes between different propagation locations, we estimated the shear wave speed, and then used it to calculate the tissue elasticity and viscosity. Preliminary phantom experiments based on this platform show results of phantom elasticity and viscosity close to literature values. Upcoming experiments are now in progress to obtain quantitative elasticity and viscosity in vitro tissue.

  • articleOpen Access

    Change of photosensitizer fluorescence at its diffusion in viscous liquid flow

    In this paper, the mathematical model of distribution of the injected compound in biological liquid flow has been described. It is considered that biological liquid contains a few phases such as water, peptides and cells. The injected compound (for example, photosensitizer) can interact with peptides and cells. At the time, viscosity of the biological liquid depends on pathology present in organism. The obtained distribution of the compound connects on changes of its fluorescence spectra which are registered during fluorescent diagnostics of tumors. It is obtained that the curves do not have monotonic nature. There is a sharp curves decline in the first few seconds after injection. Intensivity of curves rises after decreasing. It is especially pronounced for wavelength 590nm and 580nm (near the “transparency window” of biological tissues). Time of inflection point shifts from 8.4s to 6.9s for longer wavelength. However, difference between curves is little for different viscosity means of the biological liquid. Thus, additional pathology present in organism does not impact to the results of in vivo biomedical investigations.