In 2021, Li and Yan considered a more general and improved anisotropic version of the Caffarelli–Kohn–Nirenberg celebrated interpolation inequalities
∥|x|γ1|x′|αu∥Ls(ℝd)≤C∥|x|γ2|x′|μ∇u∥δLp(ℝd)∥|x|γ3|x′|βu∥1−δLq(ℝd)
in dimensions d≥2, where x=(x′,xd) and x′=(x1,…,xd−1), and gave necessary and sufficient conditions for which to hold under natural assumptions on the parameters.In this paper, we study the Li–Yan inequality with δ=1, p=2, and answer some fundamental questions concerning these inequalities such as the existence and symmetry breaking region of extremal functions, and their symmetry properties.