International Journal of Neural Systems

Emotion and affect play crucial roles in human life that can be disrupted by diseases. Functional brain networks need to dynamically reorganize within short time periods in order to efficiently process and respond to affective stimuli. Documenting these large-scale spatiotemporal dynamics on the same timescale they arise, however, presents a large technical challenge. In this study, the dynamic reorganization of the cortical functional brain network during an affective processing and emotion regulation task is documented using an advanced multi-model electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) technique. Sliding time window correlation and $k$-means clustering are employed to explore the functional brain connectivity (FC) dynamics during the unaltered perception of neutral (moderate valence, low arousal) and negative (low valence, high arousal) stimuli and cognitive reappraisal of negative stimuli. Betweenness centralities are computed to identify central hubs within each complex network. Results from 20 healthy subjects indicate that the cortical mechanism for cognitive reappraisal follows a ‘top-down’ pattern that occurs across four brain network states that arise at different time instants (0–170ms, 170–370ms, 380–620ms, and 620–1000ms). Specifically, the dorsolateral prefrontal cortex (DLPFC) is identified as a central hub to promote the connectivity structures of various affective states and consequent regulatory efforts. This finding advances our current understanding of the cortical response networks of reappraisal-based emotion regulation by documenting the recruitment process of four functional brain sub-networks, each seemingly associated with different cognitive processes, and reveals the dynamic reorganization of functional brain networks during emotion regulation.

Image anomaly detection is an application-driven problem where the aim is to identify novel samples, which differ significantly from the normal ones. We here propose Pyramidal Image Anomaly DEtector (PIADE), a deep reconstruction-based pyramidal approach, in which image features are extracted at different scale levels to better catch the peculiarities that could help to discriminate between normal and anomalous data. The features are dynamically routed to a reconstruction layer and anomalies can be identified by comparing the input image with its reconstruction. Unlike similar approaches, the comparison is done by using structural similarity and perceptual loss rather than trivial pixel-by-pixel comparison. The proposed method performed at par or better than the state-of-the-art methods when tested on publicly available datasets such as CIFAR10, COIL-100 and MVTec.

The basal ganglia (BG) represent a critical center of the nervous system for sensorial discrimination. Although it is known that Huntington’s disease (HD) affects this brain area, it still remains unclear how HD patients achieve paradoxical improvement in sensorial discrimination tasks. This paper presents a computational model of the BG including the main nuclei and the typical firing properties of their neurons. The BG model has been embedded within an auditory signal detection task. We have emulated the effect that the altered levels of dopamine and the degree of HD affectation have in information processing at different layers of the BG, and how these aspects shape transient and steady states differently throughout the selection task. By extracting the independent components of the BG activity at different populations, it is evidenced that early and medium stages of HD affectation may enhance transient activity in the striatum and the substantia nigra pars reticulata. These results represent a possible explanation for the paradoxical improvement that HD patients present in discrimination task performance. Thus, this paper provides a novel understanding on how the fast dynamics of the BG network at different layers interact and enable transient states to emerge throughout the successive neuron populations.

Human activity recognition and neural activity analysis are the basis for human computational neureoethology research dealing with the simultaneous analysis of behavioral ethogram descriptions and neural activity measurements. Wireless electroencephalography (EEG) and wireless inertial measurement units (IMU) allow the realization of experimental data recording with improved ecological validity where the subjects can be carrying out natural activities while data recording is minimally invasive. Specifically, we aim to show that EEG and IMU data fusion allows improved human activity recognition in a natural setting. We have defined an experimental protocol composed of natural sitting, standing and walking activities, and we have recruited subjects in two sites: in-house ($N=4$) and out-house ($N=12$) populations with different demographics. Experimental protocol data capture was carried out with validated commercial systems. Classifier model training and validation were carried out with scikit-learn open source machine learning python package. EEG features consist of the amplitude of the standard EEG frequency bands. Inertial features were the instantaneous position of the body tracked points after a moving average smoothing to remove noise. We carry out three validation processes: a 10-fold cross-validation process per experimental protocol repetition, (b) the inference of the ethograms, and (c) the transfer learning from each experimental protocol repetition to the remaining repetitions. The in-house accuracy results were lower and much more variable than the out-house sessions results. In general, random forest was the best performing classifier model. Best cross-validation results, ethogram accuracy, and transfer learning were achieved from the fusion of EEG and IMUs data. Transfer learning behaved poorly compared to classification on the same protocol repetition, but it has accuracy still greater than 0.75 on average for the out-house data sessions. Transfer leaning accuracy among repetitions of the same subject was above 0.88 on average. Ethogram prediction accuracy was above 0.96 on average. Therefore, we conclude that wireless EEG and IMUs allow for the definition of natural experimental designs with high ecological validity toward human computational neuroethology research. The fusion of both EEG and IMUs signals improves activity and ethogram recognition.

Speech is controlled by axial neuromotor systems, therefore, it is highly sensitive to the effects of neurodegenerative illnesses such as Parkinson’s Disease (PD). Patients suffering from PD present important alterations in speech, which are manifested in phonation, articulation, prosody, and fluency. These alterations may be evaluated using statistical methods on features obtained from glottal, spectral, cepstral, or fractal descriptions of speech. This work introduces an evaluation paradigm based on Information Theory (IT) to differentiate the effects of PD and aging on glottal amplitude distributions. The study is conducted on a database including 48 PD patients (24 males, 24 females), 48 age-matched healthy controls (HC, 24 males, 24 females), and 48 mid-age normative subjects (NS, 24 males, 24 females). It may be concluded from the study that Hierarchical Clustering (HiCl) methods produce a clear separation between the phonation of PD patients from NS subjects (accuracy of 89.6% for both male and female subsets), but the separation between PD patients and HC subjects is less efficient (accuracy of 75.0% for the male subset and 70.8% for the female subset). Conversely, using feature selection and Support Vector Machine (SVM) classification, the differentiation between PD and HC is substantially improved (accuracy of 94.8% for the male subset and 92.8% for the female subset). This improvement was mainly boosted by feature selection, at a cost of information and generalization losses. The results point to the possibility that speech deterioration may affect HC phonation with aging, reducing its difference to PD phonation.

This paper proposes a new variant of spiking neural P systems (in short, SNP systems), nonlinear spiking neural P systems (in short, NSNP systems). In NSNP systems, the state of each neuron is denoted by a real number, and a real configuration vector is used to characterize the state of the whole system. A new type of spiking rules, nonlinear spiking rules, is introduced to handle the neuron’s firing, where the consumed and generated amounts of spikes are often expressed by the nonlinear functions of the state of the neuron. NSNP systems are a class of distributed parallel and nondeterministic computing systems. The computational power of NSNP systems is discussed. Specifically, it is proved that NSNP systems as number-generating/accepting devices are Turing-universal. Moreover, we establish two small universal NSNP systems for function computing and number generator, containing 117 neurons and 164 neurons, respectively.